Evaluation the Protective Effect of Capparis spinosa Fruits Hydroalcoholic Extract Against Nephrotoxicity Induced by Cisplatin in Rats

Abstract

The present study was carried out to evaluate the kidney abnormality changes, and nephrotoxicity  after using the cisplatine and investigate the protective effect of capparis spinosa fruit extract  against these effects and evaluate the kidney function test urea, cratenine, total protein tests and  histopathological changes of kidney . Twenty one (21) male rats were randomly divided into three groups (7 rats/ each). First group was received distilled water orally for 10 days and served as control group. Second group was received cisplatin only (10 mg/kg, i.p.) as a single dose at day 8 and served as a cisplatin treated group. Third group, was received capparis spinosa fruit extract (100 mg/kg B.W) for 10 days and 10 mg/kg cisplatin as a single dose at day 8 . The results showed that the animals that treated with cisplatine alone were severed from histopathological changes and significantly increasing in the level of (Urea, Cr and Total protein ). While the third group (that treated with hydroalcoholic extract of capparis spiosa fruit ethanol 70% ) showed decreasing in the histopathplogical changes in  kidney , also significantly decrease in the level of (Urea, Cr and Total protein ). In this study csplatine induced histopathplogical changes, alteration  and increasing in the level of (Urea, Cr and Total protein ),  while the ( hydroalcoholic extract of capparis spiosa fruit ethanol 70% ) was have ability to maintain  kidney function test .