Investigating the physiological Impact of Fenugreek Extraction on Gene Expression of Bcl-2 and p53 in Cadmium-Induced Testicular Toxicity in Male Rats
DOI:
https://doi.org/10.54174/7jta7c56Keywords:
Fenugreek, Bcl-2, p53, Cadmium, SOD, CAT, GPx and MDA.Abstract
This study examined the protective and therapeutic effects of the fenugreek (trigonella Pheenum-grace) supplementation against cadmium-inspired testicular injury in male Vistarmus. Led adult male mice were divided into four groups: control, cadmium vigor (CD), pre-propellactic methi and under the cadmium exposure (pre-FG+CD) and cadmium exposure (CD+post-FG) after medical methi. Kadmium chloride (5 mg/kg body weight) was administered for two weeks, while the Methi supplement (5% weight/weight) was given during the 8-week experimental period in the diet or during the post-exposure phase (weeks 4-8). Cadmium exposure reduced the body and testicular weight and increased oxidative stress by increasing the level of freight slide (MDA) and reduced antioxidant enzyme activities (SOD, Cat, GPX). Jean-expression analysis revealed the significant decline of anti-apoptotic BCL-2 genes and an upgrade of the Pro-APPTIC P53 gene in the cadmium-powerful group. Prophylactic method supplements showed better protective effects than medical intervention, which significantly increases cadmium -induced changes in oxidative stress parameters and gene expression profiles. These findings suggest that Methi-Supplements, especially when administered, intensely administered, can provide protection against cadmium-inspired textile damage by reducing oxidative stress and changing the apoptic routes with potential implications for male reproductive health.
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