Effects of Rhizopus oryzae on Kidney of Albino Male Rats: Experimental Infection

Abstract

Background:Rhizopus oryzae stands out as a prominent pathogen within the Mucorales class, notorious for inciting mucormycosis, a severe and often perilous fungal infection that predominantly targets immunocompromised patients, especially those grappling with diabetes and hematologic cancers  . Materials and Methods: After confirming identification of R,oryzae, twenty of albino male rats were tested in which ten animals were infected with spores of this mold while others was used as control group. All animals were left for, sacrificed, and their Kidney_  were selected to be submitted to histopathological process. Results: R. oryzae revealed pathological changes in Kidney_ of albino male rats.  The   glomeruli demonstrated marked dilatation of Bowman’s space , accompanied by noticeable dilatation of the renal tubules ,atrophy of glomerul,necrosis of lining epithelial  of renal tubules  and necrosis of mesangial cells in glomeruli  , Degenerative alterations were observed in the epithelial lining of the renal tubules  , and some appeared as scattered foci of degeneration distributed across different areas of the renal cortex Conclusion: This study concluded that the R. oryzae has ability to occur effects on   Kidney of albino male rats. This conclusion demonstrates dangerous effects caused by this mold particularly immuncomprised patients. It may lose functions of   Kidney