The effect of some active compounds of the Aqueaus extract of Basil on some bloodhematological parameters of male rats induced with Diabetes
DOI:
https://doi.org/10.54174/4jjd7223Keywords:
Ocimum basilicum, aqueous extract, rats, hematological parametersAbstract
Diabetes mellitus is one of the major scientific problems facing the human body due to its delayed detection at its onset. It is often referred to as the silent killer. Cardiovascular disease, renal disease, and neuropathy are among the many complications that can develop in people with diabetes. The pancreatic beta cells secrete the hormone insulin. Its regulation of metabolism is crucial for maintaining normal blood sugar levels. Due to the complications caused by chemotherapy and its high cost, medicinal herbs have been used in this field to reduce the effects of diabetes and lower blood levels. One such herb is basil. Its aqueous leaf extract is used to treat diabetes, given its content of active compounds such as flavonoids, alkaloids, saponins, and other compounds.
Forty adult male albino rats were evaluated. They weighed between 200 and 250 grams and were 10 to 12 weeks old. Four groups were formed from them. A control group, which did not receive any therapy, was the first. On the other hand, 150 mg/kg bw of alloxan was administered to the second group. The third set of subjects received alloxan injections and a monthly dosage of 250 mg/kg bw of water-based basil leaves extract. The fourth set of subjects received a single alloxan injection, along with a monthly dosage of aqueous basil leaves extract (500 mg/kg body weight). Following the injection of alloxan, the findings demonstrated a significant decline (p < 0.05) in the quantity of red blood cells, compressed cell volume, and hemoglobin concentration. As shown in the control group, the levels increased once more after administering the aqueous basil leaf extract. Nevertheless, in contrast to the control group, the alloxan injection resulted in a substantial increase (p<0.05) in the number of white blood cells. It dropped down to levels similar to the control group after the administration of the water-based basil leaves extract (p<0.05).
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References
Anthony, U. M., Adebimpe, O. A. (2009). Hypoglycemic potential of the young leave methanolic extract of Magnifera indica in allexa-induced diabetic rats. Pakistan J. Nutrition, 8 (3), 239-241.
Babu V., Gangadevi T. and Subramoniam A. (2003). Antidiabetic activity of ethanol extract of Cassia kleinii leaf in streptozotocin-induced diabetic rats and isolation of an active fraction and toxicity evaluation of the extract. J. Pharmacol. Indian., 35:290-296
Berb, A., Rahmadika, N., Tjabjadi, A.I., and Ruslami, R. (2020). Type 2 diabetes and its impact on
the immune system. Current Diabetes Reviews, 16(5), 442–449
Chaudhary, S., Semwal, A., Kumar, H., Verma, H. C., & Kumar, A. (2016). In-vivo study of anti-hyperglycemic potential of basil seed extract (Ocimum basilicum). Biomedicine & Pharmacotherapy. Advance online publication. https://www.sciencedirect.com
Cryer, P.E. (2013). Mechanisms of hypoglycemia-associated autonomic failure in diabetes.
Eng. J. Med. 369: 362–372
Hillman, R.S., and Ault, K.A. (2002). Hematology in clinical practice. 3rd ed., McGraw-Hill, pp. 46-47
Khan, R.M.M., Chua, Z.J.Y., Tan, J.C., Yang, Y., Liao, Z.Y., and Zhao, Y. (2019). From pre-diabetes
to diabetes: diagnosis, treatments and translational research. Medicina .SS(9),546
Magliano, D.J., Islam, R.M., Barr, E.L., Gregg, E.W., Pavkov, M.G., Harding, J.L., and Shaw, J.E. (2019). Trends in incidence of total or type 2 diabetes: systematic review. BMJ, 366
Mansi, K., and Lahham, J. (2008) Effects of Artemisia Sieberi (BesserHerba-Alba) on Heart Rate and Some Hematological Values in Normal and Alloxan-Induced Diabetic Rats. Journal of Basic and Applied Sciences Vol. 4, No. 2, 57-62
Rajesh, K.; Shivanar, A.; Poornim, P.; Krithamy, P.; Kingshuk, P.; Sarah, C.; Deepti, P. and
Subarna, R. (2023). Antidengue activity of lipophilic fraction of Ocimum basilicum
Renovaldi D, Adam AK (2020) Potential of Sweet Basil (Ocimum basilicum) as a Hepatoprotector Agent for Liver Injury Related to Drugs. Muhammadiyah Medical Journal 1 63-68.
Rao GU, Kamath C, Raghothama KSP, Rao P (2003). Maternal and fetal indicators of oxidative stress in various obstetric complications. Ind. J. Clin. Biochem. 18:80-86
Saydah, SH. (2017). Medication use and selfcare practices in person with diabetes. Diabetes
in America, 3rd ed. Bethesda, MD: National Institutes of Health
Shahrajabian, M. H.; Sun, W.; Cheng, Q.,(2020): Chinese Herbal Medicine
for SARS and SARS-CoV-2 Treatment and Prevention, Encouraging
Using Herbal Medicine for COVID-19 Outbreak. Acta Agric. Scand.
B- Soil Plant Sci. 2020. DOI: 10.1080/09064710.2020.1763448
Sturkie, P.D. (1986). Avian physiology. 4th ed. Springer Velag, New York, INC.
Sunmonu, T. and Anthony J. Afolayan (2013) Evaluation of Antidiabetic Activity and Associated Toxicity of Artemisia afra Aqueous Extract in Wistar Rats. Hindawi Publishing Corporation. Evidence-Based Complementary and Alternative Medicine Article ID 929074, 8 pages
Teofilović, B., Tomas, A., Martić, N., Stilinović, N., Ćapo, I., Grubić-Letić, N., Gligorijev, E.,
& Rašković, A. (2025). Therapeutic potential of basil (Ocimum basilicum L.) aqueous extract: Impact on glycemia and oxidative stress in normoglycemic and diabetic rats. Pharmazie, 80(1), 17–23. https://doi.org/10.1691/ph.2025.4629
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