The Synergistic Impact of IL-10 Gene Polymorphisms and Epidemiological Variables on Brucellosis-Induced Abortion in Ewes

Authors

  • Mohammed Laftah Munathar Department of Animal Production, College of Agriculture and Marches, University of Thi-Qar, Iraq
  • Abbas Dakheel Mutar Department of Animal Production, College of Agriculture and Marches, University of Thi-Qar, Iraq

DOI:

https://doi.org/10.54174/dywvnv12

Keywords:

Abortion, ewe, IL-10, polymorphism, brucellosis.

Abstract

The present study sought to ascertain the correlation between genetic polymorphisms of the IL-10 gene and abortion in aborted ewes, utilizing a sample size of 100 (75 aborted ewes and 25 pregnant ewes as a control group). The current study indicated that age may influence the risk of brucellosis; ewes were categorized into three age groups, with the 5-7 year age group exhibiting a considerable rise in brucellosis cases (35 out of 48 cases; 72.9%). The high incidence of brucellosis in the first age group (1-4 years) accounted for 17 out of 23 cases, representing 73.9%. In the age bracket of 8-9 years, 13 out of 48 cases (27.1%) exhibited a reduction in abortions. The findings of this study demonstrate a significant correlation between the gestational stage and the etiology of abortion. Conversely, abortion cases occurring in the first and second trimesters were ascribed to factors unrelated to Brucella melitensis. During that period, a direct sequencing method was employed for the analyzed PCR amplicons. Subsequently, the identified variations were positioned according to their locations within the corresponding genomic DNA sequences. The current results demonstrated the presence of the 117 C>G, 118 G>C polymorphisms, and C-del 256 of the IL-10 gene. The current findings indicate a non-significant connection (p value: 0.09204) between the 117C>G and 118G>C polymorphisms of the IL-10 gene polymorphisms and abortion in aborted ewes.

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References

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Published

2025-06-01

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How to Cite

Mohammed Laftah Munathar, & Abbas Dakheel Mutar. (2025). The Synergistic Impact of IL-10 Gene Polymorphisms and Epidemiological Variables on Brucellosis-Induced Abortion in Ewes. University of Thi-Qar Journal of Agricultural Research, 14(1), 313-328. https://doi.org/10.54174/dywvnv12