Serological study of Crimean – Congo haemorrhagic fever in Sheep in Thi – Qar province.
DOI:
https://doi.org/10.54174/6m8xda50Keywords:
serological, CCHFV, Diagnosis, Thi-QarAbstract
Crimean – Congo hemorrhagic fever virus (CCHFV) causes a lethal tick – borne zoonotic disease with severe clinical manifestation in humans but does not produce symptomatic disease in wild or domestic animals. It is endemic in a large region of the word. One of the main indicators that the disease is endemic in a region is the presence of antibodies specific to CCHFV in animal populations. The factors contributing to differential outcomes of infection between species are not understood. Serological studies have shown sheep are important to the survival of CCHFV in nature. Nevertheless, need for more studies on this subject in Iraq.
Blood samples were taken from 200 sheep of different sex, variable age and physiological status. Only 100 samples used for physiological testes while 186 used for Microbiological test (ELISA) test. The present study was appeared a high level about (144)78.53% of positive carrier sheep while negative samples (42)21.46% in Thi – Qar province which include different regions such as Al-eakihah , Al- rifai and Al- garma region which recorded about 92.85% , 90% and 90 % respectively comparative with another region of thi qar province that appear low level of infected such as Al-fadhliya , Al-tar and Al- manar which recorded about 75%, 50% and 60.71% respectively.
The current study focused on and attempted to connect the different physiological states , sex and age with infected animals. The male sex appears ahigh level of infected about 83.92% comparative with female was appeared low level of infected by CCHF virus about 74.61%, while recorded high infected in non – pregnant about 75% comparative with pregnant about 73,80 . Also, the present study was showed ahigh level of infected in age from 5 to nine years about 82.4% comparative with another age ranges which appeared about 71.11, 78.50 %
Downloads
References
Afrah A. (2024). Sero-epidemological evaluation with pro-inflammation response to Crimean – Congo hemorrhagic fever (CCHF) in small ruminants in southern Iraq. Master Thesis , collage of veterinary mesicine. Barah university.
Al-Abriss,Abaidani IA, Fazlalipour M,Mostafavi,Leblebicioglu H,pshenichnaya N, et al. (2017). Current status of Crimean-Congo haemorrhagic fever in the World Health Organization Eastern Mediterranean Region: issues,challenges,and future directions. Int J Infect Dis;58;82-9
Flusin O, Iseni F, Rodrigues R, Paranhos-Baccala G, Crance JM, Marianneau P, et al. (2010). Crimean-congo hemorrhagic fever; basics for general practitioners. .Med(Mars);70(5-6);429-38.
Fillatre P, Revest M, Tattevin P. (2019). Crimean –Congo hemorrhagic fever: An update. Medicine et Maladies Infectieuses 49, 574-585.
Shepherd AJ. Swanepoel R, Cornel AJ, Mathee O.(1989) Experimental studies on the replication and transmission of Crimean congo hemorrhagic fever virus in some African tick species. The American Journal of Tropical Medicine and Hygiene 40, 326-331.
Spengler JR, Bergeron E, Rollin PE. (2016). Seroepidemiolgical studies of Crimean Congo hemorrhagic fever virus in domestic and wild animals. PLoS Neglected Tropical Diseases 10, e0004210.
Elliott R.M. (2014). Orthobunyaviruses: recent genetic and structural insights. Nat. Rev. Microbiol. 12:673.
Spengler J. R., Patel J. R., Chakrabarti A. K., Zivcec M., Garcia-Sastre A., Spirpolou C. F., Bergeron E.(2015) RIG-I Mediates an Antiviral response to Crimean – Congo Hemorrhagic fever virus. J. Virol.89:10219-10229.
Zivcec M., Metcalfe M. G., Albarino C.G., Guerrero L.W., Pergan S.D., Spiropoulou C.F., Bergeron E. (2015). Assessment of inhibitors of pathogenic Crimean – Congo hemorrhagic fever virus using virus-like particles. PLoS Negl. Trop. Dis 9:e0004259. Journal.pntd.
Honing JE, Osborne JC, Nichol ST. (2004). The high genetic variation of viruses pf the genus Nairovirus reflects the diversity of their predominant tick hosts. Virology 318, 10-16.
Lindeborg M, Barboutis C, Ehrenborg C, Fransson T, Jaenson TG, Lindgren PE, Lundkvist A, Nystrom F, Salaneck E, Waldenstrom J, Olsen B.(2012). Migratory birds, ticks, and Crimean – congo hemorrhagic fever virus. Emerging Infectious Diseases 18, 2095-2097.
Walker PJ, Widen SG, Wood TG, Guzman H, Tesh RB, Vasilakis N. (2016). A Global genomic characterization of nairoviruses identifies nine discrete genogroups with distinctive structural characteristics and host vector associations. The American journal of Tropical Medicine and Hygiene 94, 1107-1122.
Shayan S, Bokaean M, Shahrivar MR, Chinikar S. (2015). Crimean-Congo Hemorrhagic Fever. Lab Med;46(3):180-9.
Messina JP, Pigott DM, Golding N, Duda KA, Brownstein JS, Weiss DJ, Gibson H, Robinson TP, Gibert M, William Wint G. (2015). The global distribution of Crimean Congo haemorrhage fever. Transactions of the Royal Society of tropical Medicine and Hygiene 109, 503-513.
Ergonul, O., Tuncbilek, S. Baykam, N. Celilbas, A. and Dokuzoguz, b. (2006). Evaluation of serum levels of IL-6, IL-10, and TNF-alpha in patients with Crimean – Congo hemorrhagic fever. J Infect Dis, 193: 941-944.
Mazzola LT, Kelly-Cirino C.(2019). Diagnostic tests for Crimean Congo haemorrhagic fever: a widespread tickborne disease. BMJ Global Health 4,e001114.
Zivcec M, Scholte FE, Spiropoulou CF, Spengler JR, Bergeron E. (2016). Molecular insights into Crimean Congo hemorrhagic fever viruses 8, 106.
Messina JP, Pigott DM, Golding N, Duda KA, Brownstein JS, Weiss DJ, Gibson H, Robinson TP, Gibert M, William Wint G. (2015). The global distribution of Crimean Congo haemorrhage fever. Transactions of the Royal Society of tropical Medicine and Hygiene 109, 503-513.
Mertens M., Schmidt K., Ozkul A., Groschup M.H.( 2013). The impact of Crimean- Congo hemorrhagic fever virus on public health. Antivir.Res. 98:248-260.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Haneen H. T
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
1.png){kind=spacer}
