Study thyroid gland hormones in female with polycystic ovary syndrome: A Review




polycystic ovary syndrome, thyroid disease


  One metabolic syndrome is polycystic ovarian syndrome (PCOS) marked by polycystic ovary the hyperandrogenism, and anovulation. PCOS affects 6–10% of women in their reproductive years. It is a common condition. When no other cause can be identified, polycystic ovaries, hyperandrogenism, and/or irregular ovulation are the hallmarks of polycystic ovarian syndrome (PCOS). Since frank (overt) hypothyroidism is linked to insulin resistance, dyslipidemia, weight gain, anovulatory cycles, decreased levels of SHBG, and infertility, it shares several characteristics with the PCOS phenotype. Thyroid disorder screening is part of the recommended baseline screening for women who may be suspected of having PCOS, irregular menses, or infertility.Insulin resistance plays a role in PCOS pathogenesis.


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Azziz, R. (2004). PCOS: a diagnostic challenge. Reproductive biomedicine online, 8(6), 644-648.‏

Murri, M., Insenser, M., & Escobar-Morreale, H. F. (2014). Metabolomics in polycystic ovary syndrome. Clinica chimica acta, 429, 181-188.‏

Pasquali, R., Stener‐Victorin, E., Yildiz, B. O., Duleba, A. J., Hoeger, K., Mason, H., ... & Legro, R. S. (2011). PCOS Forum: research in polycystic ovary syndrome today and tomorrow. Clinical endocrinology, 74(4), 424-433.‏

Mukherjee, A. G., Wanjari, U. R., Kannampuzha, S., Murali, R., Namachivayam, A., Ganesan, R., ... & Gopalakrishnan, A. V. (2023). The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review. Metabolites, 13(1), 129.‏

Olure, B. (2023). Mental health experiences of people living with polycystic ovary syndrome (PCOS) (Doctoral dissertation, University of British Columbia).‏

Saadia Z. Follicle Stimulating Hormone (LH: FSH) Ratio in Polycystic Ovary Syndrome (PCOS) - Obese vs. Non- Obese Women. Med Arch [Internet]. 2020 Aug [cited 2023 Mar 125 1];74(4):289–93.

Chen P, Zirkin BR, Chen H. Stem Leydig Cells in the Adult Testis: Characterization, Regulation and Potential Applications. Endocr Rev [Internet]. 2020 Feb 1 [cited 2023 Mar 1];41(1):22–32.

Diamanti-Kandarakis E. Polycystic ovarian syndrome: pathophysiology, molecular aspects and clinical implications. Expert Rev Mol Med [Internet]. 2008 Jan [cited 2023 Mar 1];10:e3. Available from:

Barbieri RL, Ehrmann DA. Clinical manifestations of polycystic ovary syndrome in adults [Internet]. [cited 2023 Mar 1].

Cooney LG, Dokras A. Beyond fertility: polycystic ovary syndrome and long-term health. Fertil Steril [Internet]. 2018 Oct 1 [cited 2023 Mar 1];110(5):794–809.

Witchel SF, Burghard AC, Tao RH, Oberfield SE. The diagnosis and treatment of PCOS in adolescents: an update. Curr Opin Pediatr [Internet]. 2019 Aug [cited 2023 Mar 2];31(4):562.

Azziz R. Polycystic Ovary Syndrome. Obstet Gynecol [Internet]. 2018 Aug [cited 2023 Mar 1];132(2):321.

Elenis E, Desroziers E, Persson S, Sundström Poromaa I, Campbell RE. Early initiation of anti-androgen treatment is associated with increased probability of spontaneous conception leading to childbirth in women with polycystic ovary syndrome: a population-based multiregistry cohort study in Sweden. Hum Reprod [Internet]. 2021 May 1 [cited 2023 Mar 2];36(5):1427–35.

Lim S, Smith CA, Costello MF, MacMillan F, Moran L, Ee C. Barriers and facilitators to weight management in overweight and obese women living in Australia with PCOS: a qualitative study. BMC Endocr Disord [Internet]. 2019 Oct 23 [cited 2023 Mar 1];19(1):106.

Ismayilova M, Yaya S. “I felt like she didn’t take me seriously”: a multi-methods study examining patient satisfaction and experiences with polycystic ovary syndrome (PCOS) in Canada. BMC Womens Health [Internet]. 2022 Feb 23 [cited 2023 Feb 28];22(1):47.

Ismayilova M, Yaya S. ‘I’m usually being my own doctor’: women’s experiences of managing polycystic ovary syndrome in Canada. Int Health [Internet]. 2023 Jan 1 [cited 2023 Mar 1];15(1):56–66.

Chemerinski A, Cooney L, Shah D, Butts S, Gibson-Helm M, Dokras A. Knowledge of PCOS in physicians-in-training: identifying gaps and educational opportunities. Gynecol Endocrinol [Internet]. 2020 Oct 2 [cited 2023 Mar 1];36(10):854–9.

Glintborg, D., Rubin, K. H., Nybo, M., Abrahamsen, B., & Andersen, M. (2019). Increased risk of thyroid disease in Danish women with polycystic ovary syndrome: a cohort study. Endocrine connections, 8(10), 1405-1415.‏

Dusenbery M. Doing harm: The truth about how bad medicine and lazy science leave women dismissed, misdiagnosed, and sick. HarperOne, an imprint of HarperCollinsPublishers.

Copp T, Muscat DM, Hersch J, McCaffery KJ, Doust J, Dokras A, et al. The challenges with managing polycystic ovary syndrome: A qualitative study of women’s and clinicians’ experiences. Patient Educ Couns [Internet]. 2022 Mar 1 [cited 2023 Feb 28];105(3):719–25.

Martinez Leo, E.E.; Segura Campos, M.R. Effect of ultra-processed diet on gut microbiota and thus its role in neurodegenerative diseases. Nutrition 2020, 71, 110609.

Rajska, A.; Buszewska-Forajta, M.; Rachon, D.; Markuszewski, M.J. Metabolomic Insight into Polycystic Ovary Syndrome-An Overview. Int. J. Mol. Sci. 2020, 21, 4853.

Cardoso, N.S.; Ribeiro, V.B.; Dutra, S.G.V.; Ferriani, R.A.; Gastaldi, A.C.; Araujo, J.E.; Souza, H.C.D. Polycystic ovary syndrome associated with increased adiposity interferes with serum levels of TNF-alpha and IL-6 differently from leptin and adiponectin. Arch. Endocrinol. Metab. 2020, 64, 4–10.

Hong, X.; Qin, P.; Huang, K.; Ding, X.; Ma, J.; Xuan, Y.; Zhu, X.; Peng, D.; Wang, B. Association between polycystic ovary syndrome and the vaginal microbiome: A case-control study. Clin. Endocrinol. 2020, 93, 52–60.

Johnson, E.L.; Heaver, S.L.; Waters, J.L.; Kim, B.I.; Bretin, A.; Goodman, A.L.; Gewirtz, A.T.; Worgall, T.S.; Ley, R.E. Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels. Nat. Commun. 2020, 11, 2471.

Lemaitre, R.N.; Jensen, P.N.; Wang, Z.; Fretts, A.M.; McKnight, B.; Nemet, I.; Biggs, M.L.; Sotoodehnia, N.; de Oliveira Otto, M.C.; Psaty, B.M.; et al. Association of Trimethylamine N-Oxide and Related Metabolites in Plasma and Incident Type 2 Diabetes: The Cardiovascular Health Study. JAMA Netw. Open 2021, 4, e2122844.

Annunziata, G.; Ciampaglia, R.; Capo, X.; Guerra, F.; Sureda, A.; Tenore, G.C.; Novellino, E. Polycystic ovary syndrome and cardiovascular risk. Could trimethylamine N-oxide (TMAO) be a major player? A potential upgrade forward in the DOGMA theory. Biomed. Pharm. 2021, 143, 112171.

Abraham Gnanadass, S.; Divakar Prabhu, Y.; Valsala Gopalakrishnan, A. Association of metabolic and inflammatory markers with polycystic ovarian syndrome (PCOS): An update. Arch. Gynecol. Obs. 2021, 303, 631–643.

Torres, P.J.; Siakowska, M.; Banaszewska, B.; Pawelczyk, L.; Duleba, A.J.; Kelley, S.T.; Thackray, V.G. Gut Microbial Diversity in Women with Polycystic Ovary Syndrome Correlates with Hyperandrogenism. J. Clin. Endocrinol. Metab. 2018, 103, 1502–1511.

Sinha U, Sinharay K, Saha S, Longkumer TA, Baul SN & Pal SK. Thyroid disorders in polycystic ovarian syndrome subjects: a tertiary hospital based cross-sectional study from Eastern India. Indian Journal of Endocrinology and Metabolism 2013 17 304–309. (doi:10.4103/ 2230-8210.109714)

Kachuei M, Jafari F, Kachuei A & Keshteli AH. Prevalence of autoimmune thyroiditis in patients with polycystic ovary syndrome. Archives of Gynecology and Obstetrics 2012 285 853–856. (doi:10.1007/ s00404-011-2040-5)

Anaforoglu I, Topbas M & Algun E. Relative associations of polycystic ovarian syndrome vs metabolic syndrome with thyroid function, volume, nodularity and autoimmunity. Journal of Endocrinological Investigation 2011 34 e295–e264. (doi:10.3275/7681)

Du D & Xuelian L. The relationship between thyroiditis and polycystic ovary syndrome: a meta-analysis. International Journal of Clinical and Experimental Medicine 2013 6 880–889.

Jung JH, Hahm JR, Jung TS, Kim HJ, Kim HS, Kim S, Kim SK, Lee SM, Kim DR, Choi WJ et al. A 27-year-old woman diagnosed as polycystic ovary syndrome associated with Graves’ disease. Internal Medicine 2011 50 2185–2189. (doi:10.2169/internalmedicine.50.5475).

Ulrich, J., Müller-Wieland, D., Keck, C., & Janssen, O. E. (2013). Thyroid and Polycystic Ovary Syndrome. Der Nuklearmediziner, 36(04), 229-232.‏







How to Cite

Study thyroid gland hormones in female with polycystic ovary syndrome: A Review. (2024). University of Thi-Qar Journal of Agricultural Research, 13(1), 9-16.