Study of Reproductive efficiency and Histological Changes in Liver and Kidney Associated With Sub acute and Acute Dose of Chlorpromazine (Largctil) in Mice Mus Musculus

Abstract

The study was conducted on laboratory mice with body weight of 20-25 g . The male mice was divided into three groups (A, B and C) each group contain three replicate and each replicate contain 5 animals. A and B group were treated orally with (1.8 and 3.6mg /kg/day) respectively, while C group used as control and orally given 0.9 % normal saline and determined the histological parameters during ( 21 days) and the second part of experiment was divided into 3 group from female mice each group consist of (6) female first the control treated with (0.9%Nacl) while the (second , third group) treated with chlorpromazine (1.8 and 3.6 mg /kg/day for 14 days before matting and then all females they were gathered to mate with normal male for sixteen days.

   The histological study showed In both doses of Chlorpromazine of liver and kidney was represent by necrosis, vacuolization, hemorrhage, and complete cell membrane degeneration in hepatocytes and kidney cells, as well as recorded the lymphocytes infiltration in treated group, While the control not showed any histopathological changes during the study. The results of second experiment show all females of experiment except the third group which treated with (3.6 )mg from chlorpromazine not conceive and delivered but the control group and second group was conceive.