Protective Role of Polyphenolic Compounds of Cyperus Rotundus and Taurine on Troponin –I and Lipid Profile of Female Rats treated with Isoproterenol – Induced Myocardial Infraction.
The present study was designed to investigate the effects of polyphenolic compounds extracted from tubers of cyperus rotundus and taurine on isoproterenol induced myocardial infraction in female rats. Sixty of female rats (Rattus norvegicus) were used in the present study. Animals were divided into 10 groups ( 6 for each group). MI was induced in rats with ISO (85 mg/kg) twice at an interval of 24 hrs. ISO produced significant alterations in the troponin-I, cholesterol (TC), triglycerides (TG), HDL, vLDL, LDL and atherogenic index. The effect of polyphenolic compounds from tuberus of cyperus rotundus oral treatment for 21 days at two doses (15 mg and 30 mg/kg, body weight) and taurine at two doses ( 100 mg and 200 mg/kg, body weight) was evaluated against ISO- induced cardiac necrosis. The results showed a significant increase in the level of serum troponin-I, cholesterol(TC), triglycerides(TG), vLDL, LDL and atherogenic index in ISO- treated animals as compared with the control animals. While, the results showed asignificant decrease in the level of serum HDL in ISO- treated animals as compared with the control animals. Polyphenolic compounds from tuberus of cyperus rotundus and taurine showed a significant cardioprotective activity by lowering the levels of serum troponin-I, cholesterol(TC), triglycerides(TG), vLDL, LDL and atherogenic index and elevate the levels of serum HDL. This study concluded that the polyphenolic compounds from tuberus of cyperus rotundus and taurine possess cardioprotective activity against Isoproterenol induced myocardial infraction in rats.
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